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Publication 1: Gram Scale Synthesis of Azetidinium Salts in Flow

Vile and co-workers have reported a practical procedure for the on-demand preparation of synthetically useful azetidinium salts via aminolysis of epichlorohydrin under continuous flow conditions. Using the Uniqsis FlowLab flow chemistry reactor system, the procedure is both simple and scalable affording high yields of products that can be isolated directly within 60 minutes at 80oC. Typically higher yields are obtained in flow than in the corresponding batch process.

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Publication 2: Continuous Flow Synthesis of Indoles by Pd-Mediated Reduction of o-Nitrostilbenes with Carbon Monoxide

The Pd-mediated reduction of o-nitrostilbenes in the presence of carbon monoxide is reported to proceed regioselectively under pressurised flow-through conditions to cleanly afford indoles. A variety of substrates are tolerated and the reaction proceeds significantly faster than in batch and produces carbon dioxide as the only stoichiometric side-product.

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平推流化學（Plug Flow Chemistry）

平推流是流動反應器的關鍵特性，指初始時刻進入反應器的任意兩個分子，將在相近時間內(nèi)流出反應器。平推流反應器（PFR）模型為反應時間控制提供了有效手段，同時可優(yōu)化反應物與產(chǎn)物的分離效果。除少數(shù)特殊應用場景外，良好的平推流狀態(tài)是保障反應器高性能的核心 —— 其意味著流體以時間有序的方式通過反應器，且無返混現(xiàn)象。采用平推流化學技術的反應器通常稱為平推流反應器（PFR）。

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